NAD (nicotinamide adenine nucleotide) is a naturally-occurring coenzyme which is required for over 500 enzymatic reactions in the human body. It plays key roles in the regulation of many major biological processes. Recent research has shown NAD to be a key regulator of cellular processes that control the body’s response to stress. Some medical conditions as well as medications used to treat chronic medical conditions may deplete NAD circulating in our bodies. A decline in NAD during aging is believed to be a major cause of disease and disability. NAD boosters, small molecules that raise NAD levels, are highly promising for the treatment of multiple diseases and the potential lengthening of the human lifespan. It can even be utilized in addiction recovery for alcohol, nicotine, and opioids.